Everyone's abuzz about bringing the Web offline. Not shutting it down, but allowing webapps to be accessed offline.
Once you get past the initial "why would you do that?" there are some benefits. Some webapps do things desktop software simply doesn't. Many content-authoring apps don't need network access for 80%+ of their operation.
Somehow I don't see this being a huge success though. Not because it isn't a good idea, but the hassle involved. The story has already played out with Lotus Notes database replication, which personally I steer well clear of. Maybe Web 2.0 will make the required usability improvements; even so I see this as a niche.